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Nitrogranulogen enhances IL-1 production but decreases cellular sensitivity to this cytokine
B Stepień-Sopniewska1, U Ołdakowska, M Wasik
1Department of Immunology, Warsaw Medical School.
Folia Biologica
|January 1, 1991
Abstract:
An alkylating agent, nitrogranulogen, enhances the in vitro production of interleukin 1 by human monocytes. On the other hand, the drug inhibits proliferative responses of mouse thymocytes to exogenously added IL-1. Our results may shed light on the mechanisms of anti-inflammatory action of immunosuppressive agents.