Normal values for manometry performed with swallows of viscous test material

Area of Science:

• Gastroenterology
• Esophageal Physiology
• Diagnostic Testing

Background:

• Esophageal function testing often uses combined multichannel intraluminal impedance and manometry (MII-EM).
• Current manometric diagnoses rely solely on liquid swallows, potentially limiting accuracy.
• Establishing normal values for viscous swallows is essential for comprehensive esophageal assessment.

Purpose of the Study:

• To determine normal manometric values for esophageal function testing using viscous boluses.
• To enhance the diagnostic capabilities of MII-EM by incorporating viscous swallow data.
• To provide a standardized reference for interpreting manometric findings with viscous swallows.

Main Methods:

• Analysis of MII-EM studies from 80 healthy volunteers.
• Evaluation of manometric parameters including contraction amplitude, duration, distal onset velocity, and LES residual pressure.
• Comparison of parameters between liquid and viscous swallows.

Main Results:

• Viscous swallows showed higher contraction amplitudes and LES residual pressures compared to liquid swallows.
• Contraction duration was similar for both liquid and viscous swallows.
• Normal upper limits for viscous swallows were established: DEA <204 mmHg, LES residual pressure

Conclusions:

• Recommended normal values for manometry with viscous swallows include
• These values provide a normative reference for esophageal manometry using viscous boluses.
• This study contributes to more accurate esophageal motility disorder diagnosis.