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Updated: Jul 7, 2026

A Mouse 5/6th Nephrectomy Model That Induces Experimental Uremic Cardiomyopathy
Published on: November 7, 2017
[The specific features of renal dysfunction in cardiosurgical patients]
Abstract:
Subclinically insignificant glomerular filtration disturbances were found during operations under extracorporeal circulation. After termination of perfusion, dysfunction of the proximal portion of renal tubules was recorded in all patients. This may be associated with that the proximal tubules were more susceptible to ischemia. Further impairments of the distal portions of renal tubules suggest the persistence of ischemic lesions of the tubular apparatus.
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One condition associated with renal failure is uremia. Uremia is characterized by impaired glomerular filtration and fluid accumulation in the body. This condition hinders the renal clearance of drugs, resulting in drug accumulation and potential...
