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[Ioversol 350: clinical experience in skull x-ray computed tomography]
J Théron1, J P Paugam, P Courthéoux
1Optiray Laboratoire Guerbet, Aulnay-sous-Bois.
Annales De Radiologie
|January 1, 1991
Summary
Ioversol (350 mgl/ml), a new contrast agent, demonstrated high diagnostic accuracy and safety in cranial computed tomography scans. This nonionic, low-osmolality medium is well-tolerated by patients, proving effective for diagnostic imaging.
Area of Science:
- Radiology
- Medical Imaging
- Contrast Media
Background:
- Nonionic, low-osmolality contrast media offer improved safety profiles.
- Ioversol is a novel nonionic monomeric agent with high hydrophilicity.
Purpose of the Study:
- To evaluate the diagnostic efficacy and safety of ioversol (350 mgl/ml) in cranial computed tomography (CT).
Main Methods:
- An open trial involving 40 patients undergoing cranial CT.
- Administration of ioversol at a mean dose of 1 ml/kg.
Main Results:
- 100% diagnostic success rate with a mean certainty of 90.8%.
- Six minor adverse reactions reported, all requiring no treatment.
- Minimal heat sensations and no pain reported by patients.
Conclusions:
- Ioversol 350 mgl/ml exhibits excellent diagnostic efficacy for cranial CT.
- The contrast agent is well-tolerated, indicating a favorable safety profile.
- Ioversol is suitable for routine use in cranial CT examinations.