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Comparison of lipid amphotericin B preparations in treating murine zygomycosis

Ashraf S Ibrahim1, Teclegiorgis Gebremariam, Mohamed I Husseiny

  • 1Division of Infectious Diseases, Los Angeles Biomedical Research Institute at Harbor-University of California--Los Angeles Medical Center, Torrance, CA 90502, USA. ibrahim@labiomed.org

Antimicrobial Agents and Chemotherapy
|January 30, 2008
PubMed

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Amphotericin B is a broad-spectrum antifungal agent that exploits structural differences between fungal and mammalian cell membranes. Its amphipathic structure—featuring a hydrophobic polyene-lactone ring and a hydrophilic region containing mycosamine and carboxylic acid groups—enables selective binding to ergosterol, a sterol predominantly found in fungal plasma membranes. This selective interaction underlies the drug’s antifungal activity, although weak binding to cholesterol contributes to...