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Related Experiment Video

Updated: Jul 7, 2026

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Quantifying Tissue-Specific Proteostatic Decline in Caenorhabditis elegans

Published on: September 7, 2021

Cystatin C and aging success.

Mark J Sarnak¹, Ronit Katz, Linda F Fried

¹Department of Medicine, Tufts-New England Medical Center, Boston, Massachusetts 02111, USA. msarnak@tufts-nemc.org

Archives of Internal Medicine

|January 30, 2008

Summary

Kidney function, measured by cystatin C, impacts successful aging. Higher cystatin C levels, even within normal kidney function ranges, are linked to reduced successful life years and increased disability in older adults.

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Area of Science:

Gerontology
Nephrology
Public Health

Background:

The impact of kidney function on successful aging remains largely unexamined.
Successful aging is a multidimensional concept encompassing physical, cognitive, and disease-free status.

Purpose of the Study:

To investigate the association between kidney function, indicated by cystatin C levels, and the success of aging.
To determine if cystatin C predicts physical and cognitive disability in older adults.

Main Methods:

A 6-year follow-up study of older adults (aged >= 65) from the Cardiovascular Health Study.
Cystatin C levels were measured, and successful aging was defined by the absence of major diseases and intact physical/cognitive function.
Statistical models (accelerated failure time and Cox proportional hazards) were used to analyze the relationship between cystatin C and aging outcomes.

Main Results:

Higher cystatin C levels were associated with a significant reduction in successful life years (27% decrease).
Elevated cystatin C independently predicted incident cognitive or physical disability (HR 1.39).
These associations were observed even within a range of relatively normal kidney function.

Conclusions:

Kidney function, as assessed by cystatin C, is a significant factor in successful aging.
Higher cystatin C levels are a marker for unsuccessful aging and increased risk of disability in older adults.