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Polymorphism and solvatomorphism 2006.

Harry G Brittain¹

¹Center for Pharmaceutical Physics, 10 Charles Road, Milford, New Jersey 08848, USA. hbrittain@centerpharmphysics.com

Journal of Pharmaceutical Sciences

|January 30, 2008

Summary

This review summarizes 2006 research on polymorphism and solvatomorphism, covering crystal structures with identical or solvent-included elemental compositions. It highlights computational, preparative, and characterization studies, including patents.

Area of Science:

Solid-state chemistry
Crystallography
Materials science

Background:

Polymorphism involves different crystal structures of the same compound.
Solvatomorphism describes crystal structures incorporating solvent molecules.
Understanding these phenomena is crucial in pharmaceuticals and materials science.

Purpose of the Study:

To provide a comprehensive overview of polymorphism and solvatomorphism research published in 2006.
To consolidate findings from major scientific journals and patent literature.
To categorize and analyze advancements in the field.

Main Methods:

Literature review of articles and patents from 2006.
Categorization of studies into thematic sections.

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Analysis of computational, theoretical, preparative, and characterization data.

Main Results:

A wide range of studies on polymorphic and solvatomorphic systems were published.
Significant advancements were noted in computational modeling, synthesis, and characterization techniques.
Phase transformations and secondary processing effects were key areas of investigation.

Conclusions:

The year 2006 saw continued significant research in polymorphism and solvatomorphism.
Interdisciplinary approaches combining theory, experiment, and patent analysis are vital.
Further research is needed to fully understand and control these crystal phenomena.