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[Blood platelet cyclic AMP and prostaglandin E1 before and during post-operative venous thrombosis]
The intracellular level of cyclic AMP and PGE1 in platelets of 19 patients before and on the third day after surgery was measured. Among these 19 patients, 11 developed venous thrombosis in the legs early after surgery. We found no correlation between the occurrence of thrombosis and the initial level of cyclic AMP of PGE1. Nevertheless, after surgery the mean values of cyclic AMP or PGE1 in both the groups with or without thrombosis were significantly decreased. For PGE1 levels statistical analysis of variance showed a significant difference between the individual variations, pointing out an "individual factor".
The intracellular level of cyclic AMP and PGE1 in platelets of 19 patients before and on the third day after surgery was measured. Among these 19 patients, 11 developed venous thrombosis in the legs early after surgery. We found no correlation between the occurrence of thrombosis and the initial level of cyclic AMP of PGE1. Nevertheless, after surgery the mean values of cyclic AMP or PGE1 in both the groups with or without thrombosis were significantly decreased. For PGE1 levels statistical analysis of variance showed a significant difference between the individual variations, pointing out an "individual factor".