Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inflammatory response modulated by pinealectomy: effect of light.

R A Lobo1, E A Limãos

  • 1Departamento de Fisiologia, Escola Paulista de Medicina, São Paulo, Brasil.

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Medicas E Biologicas
|January 1, 1991
PubMed
Summary

The pineal gland, influenced by light, inhibits inflammation. Pinealectomy reduces this effect, suggesting melatonin and glucocorticoids interact peripherally to control inflammatory responses.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Impact of estetrol (E4) on hemostasis, metabolism and bone turnover in postmenopausal women.

Climacteric : the journal of the International Menopause Society·2022
Same author

Hormone replacement therapy - where are we now?

Climacteric : the journal of the International Menopause Society·2021
Same author

Metabolic and cardiovascular effects of TX-001HR in menopausal women with vasomotor symptoms.

Climacteric : the journal of the International Menopause Society·2019
Same author

Correction to: Factors associated with short interpregnancy interval among women treated with in vitro fertilization.

Journal of assisted reproduction and genetics·2018
Same author

Factors associated with short interpregnancy interval among women treated with in vitro fertilization.

Journal of assisted reproduction and genetics·2018
Same author

Menopausal hormone therapy for primary prevention: why the USPSTF is wrong.

Climacteric : the journal of the International Menopause Society·2017

Area of Science:

  • Endocrinology
  • Immunology
  • Neuroscience

Background:

  • The pineal gland and adrenal glands interact, with glucocorticoids influencing inflammation.
  • The pineal gland produces melatonin, a hormone with known immunomodulatory effects.

Purpose of the Study:

  • To investigate the effect of the pineal gland on carrageenan-induced paw edema in rats.
  • To explore the interplay between the pineal gland, adrenal hormones, and the inflammatory response.

Main Methods:

  • Carrageenan-induced paw edema model in female Wistar rats.
  • Surgical procedures: adrenalectomy, pinealectomy, sham-pinealectomy under different light conditions (white and red light).
  • Paw volume measurement using the plethysmographic method.

Related Experiment Videos

Main Results:

  • Adrenalectomy significantly increased the inflammatory response.
  • Pinealectomy and sham-pinealectomy under white light inhibited the inflammatory response.
  • Sham-pinealectomy under red light did not alter the inflammatory response, indicating light sensitivity of the pineal gland during the procedure.
  • Adrenal gland weight and corticosterone levels remained unchanged across groups.

Conclusions:

  • The pineal gland, modulated by light, exerts an inhibitory effect on acute inflammation.
  • An antagonistic interaction between melatonin and glucocorticoids at the peripheral level is proposed.
  • Glucocorticoid dominance over melatonin may explain the anti-inflammatory effect observed after pinealectomy.