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Updated: Jul 7, 2026

A Novel Stromal Fibroblast-Modulated 3D Tumor Spheroid Model for Studying Tumor-Stroma Interaction and Drug Discovery
Published on: February 28, 2020
[Tumor-stroma interactions]
Clotilde Billottet1, Jacqueline Jouanneau
1U889 Inserm, Biologie cellulaire et moléculaire, 2, rue Robert-Escarpit, 33607 Pessac Cedex, France. c.billottet@iecb.u-bordeaux.fr
Abstract:
It is widely accepted that the development of carcinoma is not only due to somatic mutations in epithelial cells but also is influenced by the tumor microenvironment ie the stroma. The different stroma components produced growth factors, cytokines, the extra cellular matrix and also participated to the recruitment of the endothelial cells necessary for the tumor neovascularisation. The stroma favored the oncogenesis through synergistic reciprocal paracrine signals with the tumor cells. The stroma is determinant for the tumor progression and therefore is an important therapeutic target.
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