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Global left-ventricular function by tissue Doppler imaging in pediatric dialysis patients
Tayfun Uçar1, Ercan Tutar, Fatoş Yalçinkaya
1Department of Pediatric Cardiology, Ankara University School of Medicine, Huzur Mah. 25 Sokak, No: 6, 11 Oveçler, Ankara, Turkey, tayfunucar@yahoo.com
Pediatric Nephrology (Berlin, Germany)
|January 31, 2008
Summary
Children with end-stage renal disease (ESRD) show impaired left-ventricular (LV) myocardial performance. Tissue-Doppler imaging revealed significant LV dysfunction and higher LV mass index in ESRD patients, highlighting hypertension as a key risk factor.
Area of Science:
- Pediatric Cardiology
- Nephrology
- Cardiovascular Imaging
Background:
- Cardiovascular abnormalities are prevalent in pediatric end-stage renal disease (ESRD).
- Left-ventricular (LV) dysfunction is a significant concern in children with ESRD.
Purpose of the Study:
- To evaluate left-ventricular (LV) myocardial performance in children with ESRD using tissue-Doppler imaging (TDI).
- To assess the relationship between LV mass index (LVMI), blood pressure, and myocardial performance in pediatric ESRD patients.
Main Methods:
- Conventional M-mode echocardiography, pulsed-wave Doppler (PWD), and TDI were used.
- Twenty-five pediatric ESRD patients and 25 healthy controls were assessed.
- Myocardial Performance Index (MPI) and LV mass index (LVMI) were calculated and compared.
Main Results:
- ESRD patients exhibited significantly higher systolic and diastolic blood pressure (BP) compared to controls.
- Mean LVMI was significantly greater in the ESRD group (p < 0.001).
- Tissue-Doppler derived MPI was significantly elevated in ESRD patients (p < 0.001), correlating with LVMI.
Conclusions:
- Pediatric patients with ESRD demonstrate significant left-ventricular (LV) myocardial dysfunction.
- Hypertension is a critical risk factor contributing to LV dysfunction in pediatric ESRD.
- TDI is a valuable tool for assessing myocardial performance in this population.
