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Related Concept Videos

Transducer Mechanism: Nuclear Receptors01:31

Transducer Mechanism: Nuclear Receptors

Nuclear receptors, or NRs, are unique transcription factors that regulate gene transcription and affect the cellular pathways involved in reproduction, development, or metabolism. Their ability to be stimulated by small lipophilic ligands and control vital cellular processes makes them ideal drug targets. Nearly 10-15% of currently prescribed drugs target these receptors.
About 48 different soluble family members of nuclear receptors are identified that can be divided into two main classes:
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
G Protein-coupled Receptors01:15

G Protein-coupled Receptors

G Protein-Coupled Receptors or GPCRs are membrane-bound receptors that transiently associate with heterotrimeric G proteins and induce an appropriate response to sensory stimuli such as light, odors, hormones, cytokines, or neurotransmitters.
GPCRs are also called heptahelical, 7TM, or serpentine receptors, and consist of seven (H1-H7) transmembrane alpha-helices that span the bilayer to form a cylindrical core. The transmembrane helices are connected by three extracellular loops and three...
Transducer Mechanism: Enzyme-Linked Receptors01:27

Transducer Mechanism: Enzyme-Linked Receptors

Enzyme-linked receptors are cell-surface receptors acting as an enzyme or associating with an enzyme intracellularly. They make excellent drug targets. Drugs can bind to the extracellular ligand-binding domain or directly affect their enzymatic domain and alter their activity.
Major types that are helpful drug targets include:
Signal Transduction: Overview01:26

Signal Transduction: Overview

Cells respond to many types of information, often through receptor proteins positioned on the membrane. They respond to chemical signals, such as hormones, neurotransmitters, and other signaling molecules, initiating a series of molecular reactions to produce an appropriate response. This is called signal transduction. Cells also coordinate different responses elicited by the same signaling molecule via mediators, allowing molecular cross-talk.
Typically, signal transduction involves three...
Drug-Receptor Interaction: Agonist01:25

Drug-Receptor Interaction: Agonist

Agonists are drugs that interact with specific receptors in the body to produce a biological response. When an agonist binds to a receptor, it activates or enhances the receptor's function, leading to physiological effects. The interaction between agonist drugs and receptors is crucial for their therapeutic action in various medical treatments.
Agonists can bind to receptors in different ways. Some agonists bind directly to the receptor's active site, mimicking the endogenous ligand's action.

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Related Experiment Video

Updated: Jul 7, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

[Advances on pregnane X receptor].

Dan Pu1, You-Fei Guan

  • 1Department of Physiology and Pathophysiology, Peking University Health Science Center, Peking University Diabetes Center, Beijing 100083, China.

Sheng Li Ke Xue Jin Zhan [Progress in Physiology]
|February 1, 2008
PubMed
Summary
This summary is machine-generated.

Pregnane X receptor (PXR) protects tissues from toxins and regulates cholesterol, lipid, and glucose metabolism. This review discusses recent advances in understanding PXR

Related Experiment Videos

Last Updated: Jul 7, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
10:51

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Pharmacology

Background:

  • The pregnane X receptor (PXR) is a nuclear receptor superfamily member.
  • PXR is primarily expressed in the liver, intestine, stomach, and kidney.
  • It plays a crucial role in detoxifying exogenous and endogenous compounds.

Purpose of the Study:

  • To review recent advances in pregnane X receptor (PXR) research.
  • To highlight PXR's role in metabolic homeostasis.
  • To discuss PXR's regulation of downstream target genes.

Main Methods:

  • Literature review of recent PXR research.
  • Analysis of studies on PXR's role in metabolism.
  • Discussion of PXR's regulatory mechanisms.

Main Results:

  • PXR is involved in regulating cholesterol homeostasis.
  • PXR influences lipid metabolism.
  • PXR plays a role in glucose homeostasis.

Conclusions:

  • PXR is a key regulator of metabolic processes.
  • Further research into PXR's functions is warranted.
  • PXR represents a potential therapeutic target for metabolic disorders.