Related Experiment Video
Updated: Oct 13, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
Published on: March 13, 2015
[Epidemiological and laboratory observations on viral hepatitis morbidity in child social welfare institutions]
A Ungureanu1, A Ivan, E Chihaia
1Institutul de Sănătate Publică şi Cercetări Medicale Iaşi.
Insights
Children in orphanages have a significantly higher incidence of viral hepatitis B. Over 21% were carriers, with young children most affected, highlighting the need for enhanced prevention strategies.
Area of Science:
- Pediatrics
- Hepatology
- Infectious Diseases
Background:
- Viral hepatitis B poses a significant public health challenge, particularly in vulnerable populations.
- Children in institutional settings may face unique risks for infectious disease transmission.
Purpose of the Study:
- To investigate the incidence and prevalence of viral hepatitis B in children residing in orphanages.
- To identify risk factors and transmission patterns within this population.
Main Methods:
- Retrospective analysis of viral hepatitis B incidence data from 1978-1987.
- Assessment of hepatitis B surface antigen (HBsAg) carrier status and case history in orphanage children.
Main Results:
- Mean incidence of viral hepatitis B was 40/100,000 in the general pediatric population versus 767/100,000 in orphanage children.
- HBsAg carrier prevalence was 21.6% overall, reaching 46.1% in orphanage children aged 0-3 years.
- 14.9% of children were HBsAg positive upon admission, and 28.7% became carriers during their stay.
Conclusions:
- Orphanage environments present a high-risk setting for viral hepatitis B transmission.
- Specialized prophylactic and control measures are crucial for viral hepatitis B in children's homes.
Abstract:
The investigations revealed that in the interval 1978-1987 the mean incidence of viral hepatitis type B in children was 40 at 100,000 inhabitants as compared to 767 in the children from orphanages. In 27.5% of the cases, the children from orphanages, with or without HBs antigen, had viral hepatitis in their case history. The prevalence of AgHBs carriers was of 21.6%, the highest value (46.1%) being recorded in the children from orphanages in the age group 0-3 years. It was also found that 14.9% of the children had AgHBs when admitted to orphanage and 28.7% became carriers later on. It is suggested that in children homes there are conditions for an increased risk requiring special measures for viral hepatitis prophylaxis and control.
Related Concept Videos
Investigation of Disease Outbreaks
Poliomyelitis
Cytomegalovirus Disease
Respiratory Syncytial Virus Disease
Hepatitis
Viral Hepatitis I: Introduction

