[Epidemiological and laboratory observations on viral hepatitis morbidity in child social welfare institutions]

A Ungureanu1, A Ivan, E Chihaia

  • 1Institutul de Sănătate Publică şi Cercetări Medicale Iaşi.

Insights

Children in orphanages have a significantly higher incidence of viral hepatitis B. Over 21% were carriers, with young children most affected, highlighting the need for enhanced prevention strategies.

Area of Science:

  • Pediatrics
  • Hepatology
  • Infectious Diseases

Background:

  • Viral hepatitis B poses a significant public health challenge, particularly in vulnerable populations.
  • Children in institutional settings may face unique risks for infectious disease transmission.

Purpose of the Study:

  • To investigate the incidence and prevalence of viral hepatitis B in children residing in orphanages.
  • To identify risk factors and transmission patterns within this population.

Main Methods:

  • Retrospective analysis of viral hepatitis B incidence data from 1978-1987.
  • Assessment of hepatitis B surface antigen (HBsAg) carrier status and case history in orphanage children.

Main Results:

  • Mean incidence of viral hepatitis B was 40/100,000 in the general pediatric population versus 767/100,000 in orphanage children.
  • HBsAg carrier prevalence was 21.6% overall, reaching 46.1% in orphanage children aged 0-3 years.
  • 14.9% of children were HBsAg positive upon admission, and 28.7% became carriers during their stay.

Conclusions:

  • Orphanage environments present a high-risk setting for viral hepatitis B transmission.
  • Specialized prophylactic and control measures are crucial for viral hepatitis B in children's homes.

Related Concept Videos

Investigation of Disease Outbreaks01:23

Investigation of Disease Outbreaks

Multistate foodborne outbreaks pose significant public health risks and require meticulous investigation to identify sources and implement control measures. The Centers for Disease Control and Prevention (CDC) utilizes a dynamic seven-step process for these investigations, integrating data from laboratories, interviews, and environmental assessments to protect public health.Outbreak Detection: The detection of multistate outbreaks typically begins with PulseNet, the CDC's national laboratory...
Poliomyelitis01:17

Poliomyelitis

Poliomyelitis is caused by poliovirus, a small, non-enveloped, positive-sense RNA virus of the Picornaviridae family and Enterovirus genus. Transmission occurs primarily via the fecal-oral route, often through ingestion of contaminated water or food. The virus initially replicates in the oropharynx and intestinal mucosa, particularly in lymphoid tissues such as the tonsils, Peyer’s patches, and regional lymph nodes. Primary viremia follows, allowing dissemination throughout the body.In most...
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
Respiratory Syncytial Virus Disease01:29

Respiratory Syncytial Virus Disease

Human respiratory syncytial virus (RSV) is a widespread pathogen that primarily targets infants and young children but also poses a serious health risk to elderly and immunocompromised individuals. Belonging to the Pneumoviridae family, RSV is a negative-sense, single-stranded RNA virus within the Pneumovirus genus. Its global health burden is significant, with millions of cases annually resulting in hospitalizations and mortality, particularly in resource-limited settings. Although most...
Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver. The...
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion of food...