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Heterogeneity in cognitive functioning among patients with bipolar disorder
Diego J Martino1, Sergio A Strejilevich, María Scápola
1Bipolar Disorders Program, Psychiatry Department, Neurosciences Institute, Favaloro Foundation, Buenos Aires, Argentina.
Journal of Affective Disorders
|February 1, 2008
Summary
Cognitive impairments in bipolar disorder (BD) are heterogeneous. Lower premorbid IQ and obstetric complications may indicate a subgroup with poorer cognitive and psychosocial functioning in BD patients.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Psychology
Background:
- The heterogeneity of cognitive impairments in bipolar disorder (BD) remains unclear.
- Identifying factors influencing cognitive deficits in BD is crucial.
Purpose of the Study:
- To investigate the heterogeneity of cognitive impairments in bipolar disorder.
- To identify variables associated with cognitive functioning in BD.
Main Methods:
- Fifty patients with BD and 30 healthy controls were assessed.
- Clinical evaluation included obstetric complications history.
- Neuropsychological testing evaluated premorbid IQ and cognitive domains.
Main Results:
- 38% of BD patients had no cognitive deficits, 40% had 1-2, and 22% had 3-5 affected domains.
- Normal cognitive functioning correlated with higher psychosocial functioning, higher premorbid IQ, and fewer obstetric complications.
- Lower premorbid IQ and obstetric complications were linked to poorer cognitive and psychosocial outcomes.
Conclusions:
- Cognitive impairments in BD are heterogeneous, impacting functional outcomes.
- A subgroup of BD patients with low premorbid IQ and obstetric complications may experience diminished cognitive and psychosocial functioning.
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