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11:13
Mass Spectrometry-Guided Genome Mining as a Tool to Uncover Novel Natural Products
Published on: March 12, 2020
Structural genomics: from genes to structures with valuable materials and many questions in between
Brian G Fox1, Celia Goulding, Michael G Malkowski
1Center for Eukaryotic Structural Genomics, University of Wisconsin-Madison, 433 Babcock Drive, Madison, Wisconsin 53706, USA. bgfox@biochem.wisc.edu
Nature Methods
|February 1, 2008
Summary
The Protein Structure Initiative (PSI) advances protein structure determination. Current efforts focus on overcoming existing methodological bottlenecks in this crucial production phase.
Area of Science:
- Structural biology
- Genomics
- Biochemistry
Background:
- The Protein Structure Initiative (PSI), funded by the US National Institutes of Health (NIH), has been instrumental in advancing the field of structural genomics.
- Global structural genomics efforts have successfully determined numerous protein structures and fostered the development of novel methodologies.
Purpose of the Study:
- To highlight the ongoing efforts within the PSI's production phase.
- To address persistent methodological bottlenecks in protein structure determination.
Main Methods:
- Systematic evaluation of protein structure solution methods.
- Development of new techniques for structural biology.
Main Results:
- Significant progress in solving protein structures.
- Advancement of methodologies for structural genomics.
Conclusions:
- Despite successes, methodological challenges remain in large-scale protein structure determination.
- The PSI continues to address these bottlenecks during its production phase.
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