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Updated: Jul 7, 2026

Fractionation for Resolution of Soluble and Insoluble Huntingtin Species
Published on: February 27, 2018
Pregnancy and active Huntington disease: a rare combination
K E Hoskins1, A T N Tita, J R Biggio
1Department of Obstetrics and Gynecology, Center for Women's Reproductive Health, University of Alabama at Birmingham, Birmingham, AL 35249-7333, USA. kelly.hoskins@obgyn.uab.edu
This case study details the complex pregnancy of a woman with advanced Huntington disease (HD). It highlights the significant challenges and multidisciplinary care required for symptomatic HD during gestation.
Area of Science:
- Neurology
- Maternal-Fetal Medicine
- Genetics
Background:
- Huntington disease (HD) is a rare, progressive neurodegenerative disorder.
- Pregnancy in women with symptomatic HD is exceptionally uncommon and presents unique clinical challenges.
Observation:
- A 31-year-old pregnant woman (gravida 2, para 1) with advanced Huntington disease was admitted at 30 weeks gestation for preterm labor.
- Her pregnancy was complicated by severe cognitive and physical decline, dysphagia, malnutrition, diabetes insipidus, aspiration pneumonia, chorioamnionitis, preterm delivery, and pyelonephritis.
Findings:
- Symptomatic Huntington disease during pregnancy leads to a high-risk obstetric course.
- Management requires intensive multidisciplinary input to address maternal and fetal complications.
Implications:
- This case underscores the need for specialized, coordinated care for pregnant women with advanced neurological conditions like HD.
- Improved understanding of HD's impact on pregnancy can guide clinical management and improve outcomes.
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