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[Thyroid malfunction in pregnancy]
D Springer1, J Horácek, D Hauerová
1UKBLD VFN a 1. LF UK, Praha.
Ceska Gynekologie
|February 2, 2008
Summary
Screening pregnant women for thyroid dysfunction is crucial, as 5% have hypothyroidism and 15% thyroid antibodies (TPOAb), risking fetal development. Early screening before or during early pregnancy is recommended.
Area of Science:
- Endocrinology
- Obstetrics & Gynecology
- Reproductive Health
Context:
- Thyroid function screening in pregnant women has been debated for over 15 years due to potential complications.
- Maternal thyroid dysfunction is linked to pregnancy complications and adverse neurodevelopmental outcomes in children.
Purpose:
- To assess thyroid parameters: thyroid-stimulating hormone (TSH), thyroperoxidase antibodies (TPOAb), and free thyroxine (FT4).
- To evaluate thyroid function in 4500 pregnant women during the first trimester across three Czech centers.
Summary:
- 5% of pregnant women exhibited subclinical hypothyroidism (elevated TSH).
- Low FT4 levels, a risk to fetal intellectual development, were found in 17 out of 120 women with TSH > 4.00 mU/l.
- Thyroid peroxidase antibodies (TPOAb) were positive in 15% of women, indicating an increased risk of thyroid malfunction.
Impact:
- The study highlights a significant prevalence of thyroid dysfunction in pregnant women.
- Results support the need for a discussion on implementing thyroid screening programs in the Czech Republic.
- Recommendations include pre-conception or early pregnancy screening and establishing systematic collaboration among healthcare professionals and laboratories for standardized diagnostic procedures.
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