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3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache
10:39

3D-Neuronavigation In Vivo Through a Patient's Brain During a Spontaneous Migraine Headache

Published on: June 2, 2014

Prevalence of migraine headaches in patients with congenital heart disease

Tam Truong1, Leo Slavin, Ramin Kashani

  • 1Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, Los Angeles, California, USA.

The American Journal of Cardiology
|February 2, 2008
PubMed

Insights

Adults with congenital heart disease (CHD) have a significantly higher prevalence of migraine headaches (MH) compared to the general population. This association suggests potential underlying mechanisms beyond intracardiac shunts.

Area of Science:

  • Cardiology
  • Neurology
  • Public Health

Background:

  • Migraine headaches (MH) affect 12% of the general population.
  • Prevalence of MH increases to 40% in patients with patent foramen ovale.
  • Congenital heart disease (CHD) is associated with increased MH risk.

Purpose of the Study:

  • To evaluate the prevalence of MH in adult patients with CHD.
  • To compare MH prevalence in CHD patients with different shunt types and controls.
  • To explore potential mechanisms linking CHD and MH.

Main Methods:

  • A questionnaire-based study of 395 adult CHD patients from UCLA Adult Congenital Heart Disease Center.
  • Patients stratified by right-to-left, left-to-right, or no shunt.
  • Comparison with 252 sex-matched controls with acquired cardiovascular disease.

Main Results:

  • MH prevalence was 45% in adults with CHD versus 11% in controls (p<0.001).
  • Migraines with aura were more common in CHD patients (80%) than controls (36%).
  • MH prevalence increased with shunt severity: 52% (right-to-left), 44% (left-to-right), 38% (no shunt).

Conclusions:

  • Adults with CHD exhibit a 3-4 times higher prevalence of MH than controls.
  • MH frequency increases with shunt severity in CHD patients.
  • The high MH prevalence in CHD patients without shunts suggests non-shunt-related mechanisms contributing to this association.

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