Reconstructive elasticity imaging for large deformations

A method is presented to reconstruct the elastic modulus of soft tissue based on ultrasonic displacement and strain images for comparatively large deformations. If the average deformation is too large to be described with a linear elastic model, nonlinear displacement-strain relations must be used and the mechanical equilibrium equations must include high order spatial derivatives of the displacement. Numerical methods were developed to reduce error propagation in reconstruction algorithms, including these higher order derivatives. Problems arising with the methods, as well as results using ultrasound measurements on gel-based, tissue equivalent phantoms, are given. Comparison to reconstructions using a linear elastic model shows that equivalent image quality can be produced with algorithms appropriate for finite amplitude deformations.