Related Experiment Video
Updated: Jul 7, 2026

Detection of DNA Double-Stranded Breaks in Mouse Oocytes
Published on: June 23, 2023
Pharmacological correction of etoposide ovariotoxicity
T G Borovskaya1, E A Timina, A V Perova
1Institute of Pharmacology, Tomsk Research Center, Siberian Division of Russian Academy of Medical Sciences, Russia.
Abstract:
The possibility of reducing the ovariotoxicity of antitumor drug etoposide with buserelin, a hypothalamic regulator of pituitary function, was studied in female Wistar rats. Quantitative analysis of ovarian structural and functional elements on serial sections through the entire organ showed that 3 months after combined treatment with etoposide and buserelin, the morphological picture of the ovarian glands did not differ from that in intact animals of the same age, while etoposide monotherapy led to earlier development of atrophic processes. Six months after treatment, the number of bi- and multilayer follicles was significantly higher in rats receiving combined therapy compared to animals treated with etoposide alone.
Related Concept Videos
Pharmaceutical Poisoning: Treatment Strategies
Oogenesis
Enhanced Elimination of Poison
Antidotes serve a crucial role in counteracting the effects of poison by inhibiting enzymes responsible for producing harmful drug metabolites. In some cases, these toxic metabolites can be neutralized by endogenous cosubstrates, which are maintained at specific concentrations to prevent interaction with cellular macromolecules and subsequent cell death.
Renal excretion is the...
Dosage Regimens: Partial Pharmacokinetic Parameters
Renal Failure: Dose Adjustments
Reduced renal clearance and elimination rate are common outcomes of renal impairment. These alterations lead to a prolonged elimination half-life and an altered apparent volume of distribution for drugs. As a result, dosage adjustments are typically necessary to maintain optimal drug levels in the body.
However, dosage adjustments...
Drug Toxicity: Dose-Dependent Reactions

