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The Forced Swim Test as a Model of Depressive-like Behavior
Published on: March 2, 2015
Antidepressant-like activity of 8-Br-cAMP, a PKA activator, in the forced swim test
Piotr Brański1, Agnieszka Palucha, Bernadeta Szewczyk
1Institute of Pharmacology, Polish Academy of Sciences, Krakow, Poland.
Journal of Neural Transmission (Vienna, Austria : 1996)
|February 2, 2008
Abstract:
The PKA activator, 8-Br-cAMP, dose-dependently reduced the immobility time in the forced swim test in rats. This effect was antagonized by co-treatment with selective PKA inhibitor Rp-cAMPS. This is the first demonstration of the antidepressant-like activity of the PKA activator.
