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Updated: Jul 7, 2026

Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
H pylori eradication: a randomized prospective study of triple therapy with or without ecabet sodium
Hyung Wook Kim1, Gwang Ha Kim, Jong Yun Cheong
1Department of Internal Medicine, Bongseng Memorial Hospital, Busan, Korea.
Aim:
To investigate whether adding ecabet sodium to the standard triple therapy for H pylori infection improve eradication rate.
Methods:
Two hundred and fifty-seven H pylori-infected patients were randomly assigned to standard triple therapy (group A, n = 129) or triple therapy plus ecabet sodium (group B, n = 128). Successful eradication was defined as a negative (13)C-urea breath test 6-8 wk after completion of treatment.
Results:
After completion of therapy, 194/257 patients showed negative (13)C-urea breath test results. According to intention-to-treat analysis, the infection was eradicated in 93/129 (72.1%) patients in group A and 101/128 (78.9%) in group B (P = 0.204). Per-protocol analysis showed successful eradication in 93/118 (78.8%) patients from group A and 101/114 (88.6%) from group B (P = 0.044). There were no significant differences in the side effects experienced by the patients in the two treatment groups.
Conclusion:
Our results suggest that the addition of ecabet sodium improves the efficacy of the standard triple therapy for H pylori.
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