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[Evaluation of the product-specific standard input function for the IMP-ARG method].
Tohru Shiga1, Tomohito Kaji, Tomoya Kohno
1Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine.
Kaku Igaku. the Japanese Journal of Nuclear Medicine
|February 5, 2008
Summary
This study confirms differences in N-isopropyl-4-iodoamphetamine (123I) products, IMP(A) and IMP(B). Using the correct standard input function for each IMP product ensures accurate measurement of cerebral blood flow (mCBF).
Area of Science:
- Nuclear Medicine
- Radiopharmacology
- Neuroimaging
Background:
- Two N-isopropyl-4-iodoamphetamine (123I) products, IMP(A) and IMP(B), exhibit differing octanol extraction fractions.
- Previous reports indicated these differences, necessitating further investigation.
Purpose of the Study:
- To confirm differences in octanol extraction fractions between IMP(A) and IMP(B).
- To develop and validate a standard input function for IMP(B).
- To compare the impact of using product-specific versus non-specific input functions on measured cerebral blood flow (mCBF).
Main Methods:
- Developed a new standard input function for IMP(B) in 19 healthy volunteers.
- Compared octanol extraction fractions of IMP(A) and IMP(B).
- Calculated mCBF using both product-specific and non-specific input functions for IMP(A) and IMP(B).
Main Results:
- Octanol extraction fractions for IMP(B) were stable and significantly higher than IMP(A).
- Using IMP(B) with IMP(A)'s input function resulted in a non-significant trend towards higher mCBF.
- Using IMP(B) with its corresponding input function yielded mCBF values identical to those obtained with IMP(A) and its input function.
Conclusions:
- Product-specific standard input functions are crucial for accurate mCBF quantification with N-isopropyl-4-iodoamphetamine (123I).
- Using the correct input function ensures comparability of mCBF measurements between IMP(A) and IMP(B).
- Clinical protocols must specify the appropriate input function based on the N-isopropyl-4-iodoamphetamine (123I) product utilized.
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