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Data Acquisition Protocol for Determining Embedded Sensitivity Functions
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Published on: April 20, 2016

[Evaluation of the product-specific standard input function for the IMP-ARG method].

Tohru Shiga1, Tomohito Kaji, Tomoya Kohno

  • 1Department of Nuclear Medicine, Hokkaido University Graduate School of Medicine.

Kaku Igaku. the Japanese Journal of Nuclear Medicine
|February 5, 2008
PubMed
Summary

This study confirms differences in N-isopropyl-4-iodoamphetamine (123I) products, IMP(A) and IMP(B). Using the correct standard input function for each IMP product ensures accurate measurement of cerebral blood flow (mCBF).

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Area of Science:

  • Nuclear Medicine
  • Radiopharmacology
  • Neuroimaging

Background:

  • Two N-isopropyl-4-iodoamphetamine (123I) products, IMP(A) and IMP(B), exhibit differing octanol extraction fractions.
  • Previous reports indicated these differences, necessitating further investigation.

Purpose of the Study:

  • To confirm differences in octanol extraction fractions between IMP(A) and IMP(B).
  • To develop and validate a standard input function for IMP(B).
  • To compare the impact of using product-specific versus non-specific input functions on measured cerebral blood flow (mCBF).

Main Methods:

  • Developed a new standard input function for IMP(B) in 19 healthy volunteers.
  • Compared octanol extraction fractions of IMP(A) and IMP(B).
  • Calculated mCBF using both product-specific and non-specific input functions for IMP(A) and IMP(B).

Main Results:

  • Octanol extraction fractions for IMP(B) were stable and significantly higher than IMP(A).
  • Using IMP(B) with IMP(A)'s input function resulted in a non-significant trend towards higher mCBF.
  • Using IMP(B) with its corresponding input function yielded mCBF values identical to those obtained with IMP(A) and its input function.

Conclusions:

  • Product-specific standard input functions are crucial for accurate mCBF quantification with N-isopropyl-4-iodoamphetamine (123I).
  • Using the correct input function ensures comparability of mCBF measurements between IMP(A) and IMP(B).
  • Clinical protocols must specify the appropriate input function based on the N-isopropyl-4-iodoamphetamine (123I) product utilized.