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Diclofenac sodium delivery to the eye: in vitro evaluation of novel solid lipid nanoparticle formulation using human
Anthony A Attama1, Stephan Reichl, Christel C Müller-Goymann
1Institut für Pharmazeutische Technologie, Technische Universität Carolo-Wilhelmina zu Braunschweig, Mendelssohnstrasse 1, D-38106 Braunschweig, Germany. aaattama@yahoo.com
Abstract:
Solid lipid nanoparticles (SLNs) were prepared with a combination of homolipid from goat (goat fat) and phospholipid, and evaluated for diclofenac sodium (DNa) delivery to the eye using bio-engineered human cornea, produced from immortalized human corneal endothelial cells (HENC), stromal fibroblasts and epithelial cells CEPI 17 CL 4. Encapsulation efficiency was high and sustained release of DNa and high permeation through the bio-engineered cornea were achieved. Results obtained in this work showed that permeation of DNa through the cornea construct was improved by formulation as SLN modified with phospholipid.
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