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Related Experiment Video

Updated: Jul 7, 2026

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder
07:51

A Protocol for Measuring Cue Reactivity in a Rat Model of Cocaine Use Disorder

Published on: June 18, 2018

Longitudinal ECG changes in cocaine users during extended abstinence.

Kenneth H Levin1, Marc L Copersino, David Epstein

  • 1Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.

Drug and Alcohol Dependence
|February 5, 2008
PubMed
Summary

Cocaine use prolongs heart rhythm intervals. During withdrawal, the corrected QT (QTc) interval significantly shortens within the first week, returning toward normal levels.

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Area of Science:

  • Cardiology
  • Pharmacology
  • Addiction Medicine

Background:

  • Cocaine use is known to prolong electrocardiographic intervals like QTc, QRS, and PR.
  • The effects of cocaine withdrawal on these cardiac parameters are not well understood.

Purpose of the Study:

  • To investigate changes in electrocardiographic intervals during monitored cocaine abstinence.
  • To determine the time course of QTc, QRS, and PR interval normalization after cessation of cocaine use.

Main Methods:

  • Weekly electrocardiograms (ECGs) were recorded for 3 months in 25 cocaine users undergoing monitored abstinence.
  • Baseline ECGs were obtained approximately 20.5 hours after the last cocaine use.
  • Participants had minimal use of other substances during the study period.

Main Results:

  • Baseline QTc interval positively correlated with the total amount and daily frequency of cocaine use prior to admission.
  • A significant shortening of the QTc interval (10.5 ms) was observed during the first week of withdrawal.
  • No further significant changes in QTc interval were noted after the first week, and PR and QRS intervals remained unchanged.

Conclusions:

  • Cocaine-induced QTc prolongation appears to reverse within the first week of abstinence.
  • These findings highlight the dynamic cardiovascular effects of cocaine withdrawal.