Fast generic chiral separation strategies using electrophoretic and liquid chromatographic techniques
Hasret Ates1, Debby Mangelings, Yvan Vander Heyden
1Department of Analytical Chemistry and Pharmaceutical Technology, Vrije Universiteit Brussel-VUB, Laarbeeklaan 103, B-1090 Brussels, Belgium.
Journal of Pharmaceutical and Biomedical Analysis
|February 5, 2008
Summary
Developing effective chiral separation methods is challenging due to numerous available selectors. This study presents generic strategies for both electrophoretic and chromatographic techniques, enabling fast enantioseparation and impurity determination.
Area of Science:
- Analytical Chemistry
- Separation Science
Background:
- Numerous chiral selectors exist for electrophoretic and chromatographic techniques.
- Developing enantioseparation methods for chiral molecules presents a significant challenge.
Purpose of the Study:
- To overview generic separation strategies for chiral method development.
- To provide a framework for enantioseparation using diverse techniques.
Main Methods:
- Review of established generic strategies for chiral separations.
- Application of strategies to electrophoretic and chromatographic techniques.
Main Results:
- Identified generic strategies applicable to diverse chiral molecules.
- Demonstrated the utility of these strategies for impurity determination and enantioseparation of racemic mixtures.
- Highlighted the speed and efficiency of the proposed strategies.
Conclusions:
- Generic separation strategies offer a powerful approach to chiral method development.
- These strategies facilitate rapid enantioseparation and impurity analysis across various techniques.
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