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Updated: Jul 7, 2026
05:39
A Neonatal BALB/c Mouse Model of Necrotizing Enterocolitis
Published on: November 30, 2021
[Necrotizing enterocolitis in two infants with gastroschisis]
Summary
Necrotizing enterocolitis is rare in near-term newborns. This case study highlights its occurrence in infants post-gastroschisis surgery, emphasizing early diagnosis for better outcomes.
Area of Science:
- Neonatal surgery
- Pediatric gastroenterology
- Gastrointestinal disorders
Background:
- Necrotizing enterocolitis (NEC) is typically a disease of premature infants.
- Gastroschisis is a congenital defect requiring surgical intervention.
Observation:
- Two infants born after 36 weeks gestation developed NEC post-gastroschisis repair.
- Both infants were fed hydrolyzed cow's milk protein formula after parenteral nutrition weaning.
Findings:
- Clinical and radiological signs of NEC appeared at 1.5 and 4.5 months.
- Medical management including parenteral nutrition and refeeding led to favorable outcomes.
Implications:
- Post-neonatal digestive issues in gastroschisis patients warrant consideration for NEC.
- Early diagnosis and treatment of NEC in this population can improve prognosis.
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