Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Localization of human thyroxine absorption.

M T Hays1

  • 1Department of Veterans Affairs Medical Center, Palo Alto, CA.

Thyroid : Official Journal of the American Thyroid Association
|January 1, 1991
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Kinetics of the human thyroid trap: experience in normal subjects and in thyroid disease.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·2013
Same author

Estimation of total body iodine content in normal young men.

Thyroid : official journal of the American Thyroid Association·2001
Same author

A mathematical model for the distribution of fluorodeoxyglucose in humans.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1999
Same author

Improving informed consent in clinical trials: a duty to experiment.

Controlled clinical trials·1999
Same author

MIRD pamphlet no. 16: Techniques for quantitative radiopharmaceutical biodistribution data acquisition and analysis for use in human radiation dose estimates.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1999
Same author

The MIRD perspective 1999. Medical Internal Radiation Dose Committee.

Journal of nuclear medicine : official publication, Society of Nuclear Medicine·1999
Same journal

Stimulating Thyrotropin Receptor Antibodies Enhance the Expression of Both Thyrotropin Receptors and Insulin-Like Growth Factor 1 Receptors in Fibroblasts.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Mild Thyroid Eye Disease-The Most Common yet the Least Studied Presentation of Thyroid Eye Disease.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

In Memoriam: Lawrence Crane Wood (1935-2026).

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Trends in Management and Outcomes of Pediatric Hyperthyroidism Over Two Decades.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

Targeted Therapy-Induced Erythrocytosis in Thyroid Cancers: An Underrecognized Safety Signal from a Retrospective Study.

Thyroid : official journal of the American Thyroid Association·2026
Same journal

<i>Retraction Notice:</i> High Iodine Concentration Attenuates <i>RET/PTC3</i> Oncogene Activation in Thyroid Follicular Cells.

Thyroid : official journal of the American Thyroid Association·2026
See all related articles

This study quantifies intestinal absorption of thyroxine (T4) using radiolabeled T4 and external imaging. Results show significant absorption in the duodenum and jejunum, providing insights into T4 gastrointestinal transport.

Area of Science:

  • Endocrinology
  • Gastroenterology
  • Nuclear Medicine

Background:

  • Thyroxine (T4) absorption is crucial for maintaining euthyroid status.
  • Understanding the precise sites and rates of intestinal T4 absorption is vital for clinical management.

Purpose of the Study:

  • To quantify the distribution and transport of orally administered 131I-labeled thyroxine (T4*) throughout the human gastrointestinal tract.
  • To model intestinal T4 absorption using external imaging and multicompartmental analysis.

Main Methods:

  • Four normal subjects received oral and i.v. T4* in separate sessions.
  • External imaging quantified T4* distribution and transport in the stomach, duodenum, and jejunoileum.
  • A multicompartmental model, including gastrointestinal compartments, analyzed systemic and gut T4 dynamics.

Related Experiment Videos

Main Results:

  • Absorption rates were calculated for different intestinal segments: duodenum (15±5%), upper jejunoileum (29±14%), and lower jejunoileum (24±11%) in three subjects.
  • A fourth subject exhibited abnormally low global absorption.
  • Model projections aligned with known effects of gut abnormalities on T4 absorption.

Conclusions:

  • This study provides quantitative data on the regional intestinal absorption of thyroxine.
  • The findings contribute to a better understanding of T4 gastrointestinal physiology and potential malabsorption syndromes.