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Related Experiment Video

Updated: Jul 7, 2026

3D Whole-heart Myocardial Tissue Analysis
06:53

3D Whole-heart Myocardial Tissue Analysis

Published on: April 12, 2017

A method for quantitative display of three-dimensional regional myocardial function.

R S Schwartz, A A Bove, R C Bahn

    IEEE Transactions on Medical Imaging
    |January 1, 1985
    PubMed
    Summary

    The dynamic spatial reconstructor (DSR) accurately images 3-D left ventricular function after myocardial infarction in dogs. This 3-D CT scanning method precisely quantifies infarct size and impaired heart muscle regions.

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    Related Experiment Videos

    Last Updated: Jul 7, 2026

    3D Whole-heart Myocardial Tissue Analysis
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    3D Whole-heart Myocardial Tissue Analysis

    Published on: April 12, 2017

    In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography
    08:13

    In Vivo Quantitative Assessment of Myocardial Structure, Function, Perfusion and Viability Using Cardiac Micro-computed Tomography

    Published on: February 16, 2016

    Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging
    11:13

    Quantification of Mouse Heart Left Ventricular Function, Myocardial Strain, and Hemodynamic Forces by Cardiovascular Magnetic Resonance Imaging

    Published on: May 24, 2021

    Area of Science:

    • Cardiovascular Imaging
    • Medical Physics
    • Cardiac Surgery

    Background:

    • Myocardial infarction (MI) significantly impacts left ventricular (LV) geometry and function.
    • Accurate, quantitative assessment of infarct size and regional wall motion is crucial for patient management.
    • Existing imaging modalities may have limitations in fully characterizing 3-D LV function post-MI.

    Purpose of the Study:

    • To evaluate the dynamic spatial reconstructor (DSR) for quantitative 3-D imaging of LV wall geometry and function.
    • To assess the DSR's ability to detect and quantify myocardial dysfunction in a canine model of MI.
    • To compare DSR-derived measurements with postmortem anatomical findings.

    Main Methods:

    • Experimental induction of myocardial infarction in four dogs via left anterior descending coronary artery occlusion.
    • Scanning with the DSR, a multi-X-ray source scanner, during biatrial contrast injection at 6-14 weeks post-occlusion.
    • Quantitative analysis of 3-D LV wall motion, including systolic wall thickening rate, to identify normal, ischemic, and scarred myocardium.

    Main Results:

    • The DSR successfully generated stop-action 3-D images of the canine left ventricle.
    • Regional myocardial function, including hypokinetic segments, was accurately measured and correlated with postmortem scar size.
    • Computer-generated 3-D displays effectively visualized the extent and relationship of dysfunctional myocardium.

    Conclusions:

    • The dynamic spatial reconstructor (DSR) provides accurate 3-D quantitative imaging of left ventricular myocardial infarction.
    • This 3-D CT scanning technique clearly defines the location and extent of infarcted and ischemic myocardium.
    • The presented display methods enable precise localization and quantification of myocardial infarct volume and function.