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[Growth hormone receptor].

M C Postel-Vinay1, J Finidori, L Goujon

  • 1Unité INSERM 344, Faculté de Médecine Necker Enfants Malades, Paris.

Annales D'Endocrinologie
|January 1, 1991
PubMed
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Growth hormone (GH) actions are mediated by GH receptors. The GH-binding protein (GH-BP) in plasma reflects the GH receptor, and its absence indicates Laron dwarfism due to GH receptor gene mutations.

Area of Science:

  • Endocrinology and Molecular Biology
  • Study of hormone receptor structure and function.

Context:

  • Growth hormone (GH) has diverse physiological effects.
  • GH receptors are present in various tissues, including the liver.
  • Previous studies showed altered hepatic GH receptor numbers in growth failure models.

Purpose:

  • To describe the structure of the GH receptor and its relation to the GH-binding protein (GH-BP).
  • To investigate the utility of GH-BP as a marker for GH receptor function in vivo.

Summary:

  • The human GH receptor is a 620-amino acid protein with extracellular, transmembrane, and cytoplasmic domains, belonging to a cytokine receptor family.
  • GH-BP in plasma represents the extracellular domain of the membrane-bound GH receptor.
  • Absence of GH-BP activity was observed in patients with Laron dwarfism, linked to GH receptor gene mutations.

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Impact:

  • Provides insight into GH receptor structure and signal transduction.
  • Establishes GH-BP as a valuable diagnostic tool for Laron dwarfism and GH receptor defects.
  • Highlights the importance of the GH receptor in normal growth and development.