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Updated: Jul 7, 2026

Characterization of Leukocyte-platelet Rich Fibrin, A Novel Biomaterial
Published on: September 29, 2015
Platelet-rich fibrin: evolution of a second-generation platelet concentrate
V Sunitha Raja1, E Munirathnam Naidu
1Department of Periodontics, Meenakshiammal Dental College and Hospital, Maduravoyal, Chennai, India. sunitha.smiles@yahoo.com
Abstract:
Platelet-rich plasma (PRP) is a platelet concentrate that has been used widely to accelerate soft-tissue and hard-tissue healing. The preparation of PRP has been described by several authors. Platelet-rich fibrin (PRF) was first described by Choukroun et al. in France. It has been referred to as a second-generation platelet concentrate, which has been shown to have several advantages over traditionally prepared PRP. Its chief advantages include ease of preparation and lack of biochemical handling of blood, which makes this preparation strictly autologous. This article describes the evolution of this novel platelet concentrate, referred to as PRF.
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