Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Hypersensitivity Reactions: Immune-Complex Reactions01:19

Hypersensitivity Reactions: Immune-Complex Reactions

Type III hypersensitivity reactions occur when antigen–antibody complexes form and activate the complement system. Normally, these complexes help the clearance of antigens by phagocytes and red blood cells. However, when large numbers of immune complexes are present, they can deposit in tissues—particularly in the walls of blood vessels—leading to inflammation and tissue injury. These deposits trigger complement activation and neutrophil recruitment, resulting in serum sickness, a systemic...
Hypersensitivities01:30

Hypersensitivities

Hypersensitivity, also known as a hypersensitivity reaction or allergic reaction, is a condition where the body's immune system reacts abnormally to a foreign substance. Such substances, that cause hypersensitivity are referred to as an allergen, could be something typically harmless to most people, like pollen or certain foods.
Types of Hypersensitivities
Hypersensitivity reactions are categorized into four types: Type 1, Type 2, Type 3, and Type 4. Each type has a distinct mechanism...
Autoimmune Disorders01:29

Autoimmune Disorders

Autoimmune diseases are a group of disorders in which the body's immune system mistakenly attacks its own cells, tissues, and organs. This results from an overactive immune response against substances and tissues normally present in the body. Let's delve into the concept and mechanism of autoimmune diseases from an immune system point of view, explore different causes and examples of such diseases, and discuss potential solutions.
Concept and Mechanism of Autoimmune Diseases
The immune system...
Humoral Immune Responses01:36

Humoral Immune Responses

Overview
Gastritis-II: Pathophysiology01:17

Gastritis-II: Pathophysiology

Gastritis is marked by disruption of the mucosal barrier that usually protects the stomach tissue from digestive juices and manifests in acute and chronic forms.
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
Graves' Disease I: Introduction01:28

Graves' Disease I: Introduction

Graves' disease is an autoimmune disorder that causes hyperthyroidism, or overactivity of the thyroid gland. It results from autoantibodies called thyroid-stimulating immunoglobulins (TSIs), which bind to thyroid-stimulating hormone (TSH) receptors, leading to overstimulation of hormone production and a hypermetabolic state.EtiologyAlthough considered idiopathic, Graves’ disease has well-established contributing factors. There is a strong genetic component, with increased prevalence in...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessment of diagnostic yield and clinical utility of genome sequencing in critically ill infants.

Pediatric research·2026
Same author

Assessing the Risk Stratification of Breast Cancer Polygenic Risk Scores in a Brazilian Cohort.

The Journal of molecular diagnostics : JMD·2024
Same author

Evaluation of pediatric diabetes mellitus after SARS-CoV-2 infection: A long-term prospective case series.

Clinics (Sao Paulo, Brazil)·2023
Same author

Intracellular peptides in SARS-CoV-2-infected patients.

iScience·2023
Same author

Severe COVID-19 patients show a dysregulation of the NLRP3 inflammasome in circulating neutrophils.

Scandinavian journal of immunology·2022
Same author

A common variant close to the "tripwire" linker region of NLRP1 contributes to severe COVID-19.

Inflammation research : official journal of the European Histamine Research Society ... [et al.]·2022

Related Experiment Video

Updated: Jul 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Autoimmunity in hyper-IgM syndrome.

Adriana A Jesus1, Alberto J S Duarte, João B Oliveira

  • 1Pediatric Rheumatology Unit, Pediatrics Department, Universidade de São Paulo, Av. Dr. Enéas Carvalho de Aguiar 500 IMT Bldg. II 3rd floor, São Paulo, Sao Paulo 054030-000, Brazil.

Journal of Clinical Immunology
|February 5, 2008
PubMed
Summary
This summary is machine-generated.

Hyper-IgM (HIGM) syndrome involves defects in immune pathways, leading to infections and autoimmune issues like arthritis. Research explores HIGM subtypes and their autoimmune links, including T-cell defects and autoantibodies.

More Related Videos

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Related Experiment Videos

Last Updated: Jul 7, 2026

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis
10:27

Recognition of Epidermal Transglutaminase by IgA and Tissue Transglutaminase 2 Antibodies in a Rare Case of Rhesus Dermatitis

Published on: December 15, 2011

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity
11:12

Interrogating Individual Autoreactive Germinal Centers by Photoactivation in a Mixed Chimeric Model of Autoimmunity

Published on: April 11, 2019

Granulocyte-dependent Autoantibody-induced Skin Blistering
12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

Area of Science:

  • Immunology
  • Genetics

Background:

  • Immunodeficiency with hyper-IgM (HIGM) arises from genetic defects in CD40-CD40 ligand (CD40L) pathways or immunoglobulin class switch recombination enzymes.
  • HIGM impairs both B-cell and T-cell activation, increasing susceptibility to infections.

Purpose of the Study:

  • To review the main subtypes of Hyper-IgM syndrome.
  • To discuss the clinical autoimmune manifestations associated with HIGM.
  • To explore the underlying mechanisms linking HIGM and autoimmunity.

Main Methods:

  • Review of existing literature on Hyper-IgM syndrome subtypes.
  • Analysis of clinical data on autoimmune manifestations in HIGM patients.
  • Discussion of proposed immunological mechanisms.

Main Results:

  • Seven main subtypes of HIGM exist, with X-linked HIGM (CD40L mutations) being the most frequent.
  • HIGM patients exhibit recurrent infections and autoimmune conditions, including hematologic abnormalities, arthritis, and inflammatory bowel disease.
  • Organ-specific autoantibodies are frequently detected in HIGM patients.

Conclusions:

  • Defective regulatory T-cell development, IgM autoantibodies, and impaired peripheral B-cell tolerance are implicated in HIGM-associated autoimmunity.
  • Understanding these mechanisms is crucial for managing HIGM patients.
  • Further research is needed to fully elucidate the complex interplay between HIGM and autoimmune disorders.