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Related Concept Videos

Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
Pigmentation01:19

Pigmentation

The color of the skin is influenced by a number of pigments, including melanin, carotene, and hemoglobin. Recall that melanin is produced by cells called melanocytes, which are found scattered throughout the stratum basale of the epidermis. The melanin is transferred to the keratinocytes via melanosomes.
Melanin occurs in two primary forms: eumelanin that provides black and brown pigment and pheomelanin that provides red color. Dark-skinned individuals produce more melanin than those with pale...
Papillary Dermis01:11

Papillary Dermis

Dermis
The dermis might be considered the "core" of the integumentary system, as distinct from the epidermis and hypodermis. It contains blood and lymph vessels, nerves, and other structures, such as hair follicles and sweat glands. The dermis is made of two layers of connective tissue that comprise an interconnected mesh of elastin and collagenous fibers, produced by fibroblasts.
Papillary Layer
The papillary layer is made of loose, areolar connective tissue, which means the collagen and...
Reticular Dermis01:15

Reticular Dermis

The papillary and reticular dermis are the two layers of the dermis. They are made of connective tissue with fibers of collagen extending from one to the other, making the border between the two somewhat indistinct. The dermal papillae extending into the epidermis belong to the papillary layer, whereas the dense collagen fiber bundles below belong to the reticular layer.
Reticular Layer
Underlying the papillary layer is the much thicker reticular layer, composed of dense, irregular connective...
Accessory Structures of the Skin: Nails01:05

Accessory Structures of the Skin: Nails

Nails are one of the important accessory structures of the skin. They are hard, protective structures that cover the dorsal surface of the distal phalanges of fingers and toes. Nails are composed of specialized keratinized cells and serve various functions, including protection, sensation, and manual dexterity.
The main components of a nail include the following.
Nail Plate: The nail plate is the visible portion of the nail that extends beyond the fingertips or toes. It is a hard, translucent...
Cells of the Epidermis01:24

Cells of the Epidermis

The epidermis is made of four or five layers of epithelial cells, depending on its location in the body. From deep to superficial, these layers are the stratum basale, stratum spinosum, stratum granulosum, stratum lucidum, and stratum corneum.
The cells in all these layers except the stratum basale are called keratinocytes, a type of cell that manufactures and stores the protein keratin. The keratinocytes in the stratum corneum are dead and regularly slough away, being replaced by cells from...

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Nevus spilus.

Darshan C Vaidya1, Robert A Schwartz, Camila K Janniger

  • 1UMDNJ-New Jersey Medical School, Newark, New Jersey 07103, USA.

Cutis
|February 6, 2008
PubMed
Summary

Nevus spilus (NS), a common skin lesion, presents as pigmented spots within a patch. While its cause is unknown, NS has a slight melanoma risk, suggesting targeted speckle removal if full excision is refused.

Area of Science:

  • Dermatology
  • Oncology
  • Pathology

Background:

  • Nevus spilus (NS), or speckled lentiginous nevus (SLN), is a common melanocytic nevus.
  • It is characterized by multiple pigmented macules/papules within a larger pigmented patch.
  • The etiology of Nevus spilus remains unknown, and it can be congenital or acquired.

Purpose of the Study:

  • To discuss the classification and clinical significance of Nevus spilus.
  • To highlight the potential risk of melanoma development in Nevus spilus.
  • To propose management strategies for Nevus spilus, considering patient preferences.

Main Methods:

  • Review of existing literature on Nevus spilus.
  • Analysis of clinical characteristics and potential malignant transformation.

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  • Evaluation of diagnostic and therapeutic approaches.
  • Main Results:

    • Nevus spilus is a distinct entity in the classification of melanocytic nevi.
    • It carries a slight potential for malignant transformation into melanoma.
    • Management should consider the risk-benefit ratio of complete versus partial excision.

    Conclusions:

    • Nevus spilus warrants specific consideration within the spectrum of melanocytic nevi.
    • The slight melanoma risk necessitates awareness and appropriate monitoring.
    • Punch excision of speckles may be a viable option if complete Nevus spilus excision is declined.