TEMPE: Topical Eutectic-Like Mixture for Premature Ejaculation

Area of Science:

• Pharmacology
• Dermatology
• Urology

Background:

• Premature ejaculation (PE) is the most common male sexual dysfunction.
• Current treatments lack on-demand efficacy and rapid action.
• An unmet need exists for effective, user-controlled PE pharmaceutical interventions.

Purpose of the Study:

• To evaluate TEMPE, a novel topical eutectic-like mixture of lidocaine and prilocaine for premature ejaculation treatment.
• To explore the potential of TEMPE for other applications, such as pain relief.

Main Methods:

• TEMPE utilizes a metered-dose aerosol containing lidocaine and prilocaine in a eutectic-like mixture.
• The formulation uses hydrofluoroalkane (HFA-134a) propellant as a solvent.
• Optimized absorption is achieved through non-keratinized skin or mucous membranes.

Main Results:

• Preliminary results indicate TEMPE improves intravaginal ejaculatory latency.
• Patient-reported outcomes show promising advancements with TEMPE use.
• The novel formulation ensures controlled dosing and effective local anesthetic delivery.

Conclusions:

• TEMPE represents a novel therapeutic approach for premature ejaculation.
• The formulation demonstrates potential for improved ejaculatory control and patient satisfaction.
• Further research may explore TEMPE's utility in diverse clinical applications.