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Review article: gastroparesis.

A Patrick1, O Epstein

  • 1Centre for Gastroenterology, Royal Free Hampstead NHS Trust, London, UK.

Alimentary Pharmacology & Therapeutics
|February 6, 2008
PubMed
Summary
This summary is machine-generated.

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Gastroparesis, a stomach pump failure disorder, causes nausea and pain, often linked to diabetes. While gastric neurostimulation shows promise for severe cases, more research is needed for effective treatments.

Area of Science:

  • Gastroenterology
  • Neurology
  • Endocrinology

Background:

  • Gastroparesis is a chronic disorder characterized by stomach pump failure, leading to nausea, vomiting, and epigastric pain.
  • Diabetes is the most common known association, though the cause is often idiopathic.
  • Current diagnosis relies on isotope-labelled test meals, with incremental treatments including dietary support and medications.

Purpose of the Study:

  • To review current concepts of gastric motor function.
  • To explore the aetiology, investigation, and treatment of gastroparesis.
  • To highlight novel approaches like gastric neurostimulation.

Main Methods:

  • A systematic web-based literature review was conducted.
  • A comprehensive lexicon of gastroparesis-related terms was utilized.

Related Experiment Videos

  • The review focused on current understanding and therapeutic strategies.

    • Main Results:

    • Few controlled studies exist; causation and underlying pathology remain poorly understood.
    • Idiopathic gastroparesis predominantly affects women; diabetes frequently impairs gastric emptying.
    • Isotopic gastric scintigraphy is the gold standard, but alternative diagnostic tests are emerging. Gastric neurostimulation offers benefits for intractable cases.

    Conclusions:

    • Significant progress has been made in understanding gastroparesis.
    • Further controlled trials are essential to evaluate available therapeutic options.
    • Gastroparesis remains an intriguing condition requiring continued research.