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Related Experiment Videos

Cerebral palsy.

Michael O'Shea1

  • 1Department of Pediatrics, Wake Forest University School of Medicine, Winston-Salem, NC 27157, USA. moshea@wfubmc.edu

Seminars in Perinatology
|February 6, 2008
PubMed
Summary
This summary is machine-generated.

Extreme prematurity significantly increases cerebral palsy (CP) risk. Antenatal glucocorticoid treatment is the only intervention proven to reduce both mortality and CP risk in vulnerable infants.

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Area of Science:

  • Neurology
  • Pediatrics
  • Public Health

Background:

  • Extreme prematurity is associated with a 100-fold increased risk of cerebral palsy (CP) compared to term birth.
  • CP, primarily a motor disorder, often involves other impairments affecting quality of life and life expectancy.
  • Standardized classification systems like the Gross Motor Function Classification System (GMFCS) improve CP research.

Purpose of the Study:

  • To review advancements in cerebral palsy (CP) definition and classification.
  • To highlight the importance of quality of life measures in CP interventions.
  • To discuss trends in CP rates and effective preventative strategies.

Main Methods:

  • Review of epidemiologic and clinical studies on cerebral palsy.
  • Analysis of trends in CP rates over recent decades.

Related Experiment Videos

  • Evaluation of perinatal interventions for CP prevention.

    • Main Results:

    • CP rates rose in the late 1970s/early 1980s due to increased survival of high-risk infants.
    • CP rates have stabilized or decreased in developed countries since the late 1980s.
    • Antenatal glucocorticoid treatment is the only perinatal intervention with strong evidence for reducing both mortality and CP risk.

    Conclusions:

    • Standardized classification and quality of life assessments are crucial for CP research and intervention.
    • While CP rates have seen some decline, prevention remains a focus.
    • Antenatal glucocorticoid administration shows significant promise in mitigating CP and mortality in high-risk pregnancies.