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Updated: Jun 5, 2026

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Culturing and Maintaining Clostridium difficile in an Anaerobic Environment

Published on: September 15, 2013

Recent advances in Clostridium difficile-associated disease.

T Monaghan¹, T Boswell, Y R Mahida

¹Institute of Infection, Immunity & Inflammation, University of Nottingham and Nottingham University Hospitals NHS Trust, UK.

|February 7, 2008

Summary

This review covers new treatments for Clostridium difficile-associated disease (CDAD), including antibiotics and non-antibiotic options. It also discusses infection control and the emergence of a hypervirulent strain.

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A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

A Protocol to Characterize the Morphological Changes of Clostridium difficile in Response to Antibiotic Treatment

Published on: May 25, 2017

Area of Science:

Gastroenterology and Infectious Diseases
Microbiology and Immunology

Background:

Clostridium difficile-associated disease (CDAD) presents challenges in management due to recurrence and emerging strains.
Current treatment strategies involve antibiotics, but non-antibiotic approaches and infection control are crucial.

Purpose of the Study:

To review recent advancements in managing acute and recurrent Clostridium difficile-associated disease.
To discuss existing and novel therapeutic agents, including antibiotic and non-antibiotic options.
To explore infection control measures and the impact of hypervirulent strains.

Main Methods:

Literature review of recent developments in Clostridium difficile-associated disease management.
Analysis of current and investigational treatments, including pharmacological and surgical interventions.
Examination of pathogenesis, clinical presentation, diagnosis, and infection control strategies.

Main Results:

Several new antibiotic and non-antibiotic agents are in development for CDAD treatment.
Surgery remains a critical option for severe cases of the disease.
Effective infection control relies on antimicrobial stewardship, cross-infection prevention, and surveillance.

Conclusions:

The management of Clostridium difficile-associated disease is evolving with new therapeutic options.
A multi-faceted approach combining novel treatments, surgical intervention, and robust infection control is essential.
Understanding pathogenesis and diagnostic advancements aids in combating CDAD, especially concerning hypervirulent strains.