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Amylin peptide is increased in preterm neonates with feed intolerance
V R Kairamkonda1, A Deorukhkar, C Bruce
1Department of Neonatal Intensive Care, University Hospitals of Leicester NHS Trust, Leicester Royal Infirmary, Leicester LE1 5WW, UK. Venkatesh.Kairamkonda@uhl-tr.nhs.uk
Archives of Disease in Childhood. Fetal and Neonatal Edition
|February 7, 2008
Summary
Elevated serum amylin concentrations in preterm neonates are linked to feed intolerance and delayed gastric emptying. Higher amylin levels correlate with increased gastric residual volume and longer time to full enteral feeding.
Area of Science:
- Endocrinology
- Neonatology
- Gastroenterology
Background:
- Amylin, a peptide hormone co-secreted by pancreatic beta cells, inhibits gastric emptying.
- Feed intolerance, characterized by increased gastric residual volume (GRV), is common in preterm neonates.
- This study investigates the role of amylin in preterm neonates' feed intolerance.
Purpose of the Study:
- To determine serum amylin concentrations in feed-intolerant preterm neonates.
- To explore the relationship between serum amylin levels and gastric emptying in this population.
Main Methods:
- A case-control study comparing feed-intolerant (nTOL) and feed-tolerant (TOL) preterm neonates.
- Matched neonates based on gestation, birth weight, and postnatal age.
- Serum amylin concentrations and gastric residual volume (GRV) were measured.
Main Results:
- Serum amylin concentrations and GRV were significantly higher in the nTOL group compared to the TOL group (p<0.001).
- A positive correlation was found between serum amylin and GRV in nTOL neonates (r = 0.78, p<0.001).
- Serum amylin levels also correlated with delayed time to full enteral feeds and discharge in nTOL neonates.
Conclusions:
- Amylin may delay enteral nutrition establishment in preterm neonates due to its gastric emptying inhibition.
- Serum amylin concentrations are elevated in feed-intolerant preterm neonates.
- Amylin levels correlate with GRV and the time required to achieve full enteral feeds.
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