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Updated: Jul 7, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
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Published on: May 9, 2022

Antibiotic prophylaxis in dentistry: an update.

James W Little1, Donald A Falace, Craig S Miller

  • 1University of Minnesota, Minneapolis, USA.

General Dentistry
|February 8, 2008
PubMed
Summary

Secondary antibiotic prophylaxis in dentistry is often prescribed without strong scientific evidence, despite potential risks like antibiotic resistance and allergic reactions. This review examines the current use and necessity of these dental prescriptions.

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Last Updated: Jul 7, 2026

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease
06:06

Adjunctive Diode Laser Therapy and Probiotic Lactobacillus Therapy in the Treatment of Periodontitis and Peri-Implant Disease

Published on: May 9, 2022

Area of Science:

  • Dentistry
  • Pharmacology
  • Infectious Diseases

Background:

  • Antibiotics are utilized in dentistry for therapeutic treatment and prophylactic prevention of infections.
  • Primary prophylaxis involves preventing perioperative infections, while secondary prophylaxis aims to reduce infection risk from bacteremia in patients with existing conditions or devices.
  • The use of secondary prophylaxis in dentistry is common but often lacks robust scientific evidence of efficacy.

Purpose of the Study:

  • To review the current clinical status and scientific evidence regarding the use of secondary antibiotic prophylaxis in dental practice.
  • To evaluate the necessity and potential risks associated with current prescribing patterns of secondary antibiotic prophylaxis in dentistry.

Main Methods:

  • Literature review of current practices and scientific evidence on secondary antibiotic prophylaxis in dentistry.
  • Analysis of the benefits versus risks, including antibiotic resistance, allergic reactions, and cost-effectiveness.

Main Results:

  • Accumulating evidence suggests that many instances of secondary antibiotic prophylaxis in dentistry may be unnecessary.
  • Significant risks associated with antibiotic use include allergic reactions, development of antibiotic-resistant bacteria, superinfections, and pseudomembranous colitis.
  • The cost associated with antibiotic use can also be substantial.

Conclusions:

  • The widespread prescription of secondary antibiotic prophylaxis in dentistry is not adequately supported by scientific evidence.
  • A critical re-evaluation of current practices is needed to mitigate risks and optimize patient care.
  • Further research is required to establish evidence-based guidelines for secondary antibiotic prophylaxis in dental settings.