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Related Experiment Videos

Enhanced initial cell responses to chemically modified anodized titanium.

Ryo Jimbo1, Takashi Sawase, Koumei Baba

  • 1Division of Applied Prosthodontics, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto, Nagasaki, Japan.

Clinical Implant Dentistry and Related Research
|February 8, 2008
PubMed
Summary
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Fluoride modification of anodized titanium dioxide (TiO(2)) enhances implant hydrophilicity and improves initial cell attachment and proliferation for better bone apposition. This study optimized TiO(2) treatment for enhanced biocompatibility.

Area of Science:

  • Biomaterials Science
  • Surface Chemistry
  • Orthopedic Implants

Background:

  • Anodized porous titanium implants exhibit photocatalytic hydrophilicity.
  • This property alone is insufficient for optimal bone apposition.

Purpose of the Study:

  • To enhance photocatalytic properties of porous titanium implants via fluoride modification of anodized titanium dioxide (TiO(2)).
  • To evaluate the initial cellular response to the modified implants.

Main Methods:

  • Determined optimal ammonium hydrogen fluoride (NH(4)F-HF(2)) concentration (0.175%) using water contact angle assay.
  • Cultured C2C12 cells on fluoride-modified TiO(2) disks to assess attachment, morphology, and proliferation.

Main Results:

Related Experiment Videos

  • Significantly increased cell attachment observed on ultraviolet-irradiated, fluoride-modified anodized TiO(2) (p < .05).
  • Cells exhibited flattened, extended morphology.
  • Enhanced proliferation rates were noted after 24 hours.

    • Conclusions:

    • Fluoride chemical modification improves the hydrophilic nature of anodized TiO(2).
    • Enhanced hydrophilicity leads to a superior initial cellular response, indicating potential for improved implant osseointegration.