Related Experiment Video
Updated: Jul 7, 2026

Development of Leishmania Species Strains with Constitutive Expression of eGFP
Published on: April 21, 2023
Leishmania: conserved evolution--diverse diseases
Miriam A Lynn1, W Robert McMaster
1Immunity and Infection Research Centre, Vancouver Coastal Health Institute, and the Department of Medical Genetics, University of British Columbia, 2660 Oak Street, Vancouver, V6H 3Z6 BC, Canada.
Abstract:
The landmark completion of the Leishmania major genome sequence and the recent publication of the L. infantum and L. braziliensis genomes revealed the surprising result that, although separated by 15-50 million years of evolution, the Leishmania genomes are highly conserved and have less than 1% species-specific genes. Yet, these three species of Leishmania cause distinctive and diverse diseases in humans. Here, we discuss these findings together with recent microarray and proteomics studies and highlight their importance in understanding Leishmania disease phenotypes.
Related Concept Videos
Leishmaniasis
Antiprotozoal Agents
Malaria
Diversity of Protists II
Diversity of Protists I
American Trypanosomiasis
