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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4
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A Flow Cytometry-based Assay to Identify Compounds That Disrupt Binding of Fluorescently-labeled CXC Chemokine Ligand 12 to CXC Chemokine Receptor 4

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Overcoming undesirable HERG potency of chemokine receptor antagonists using baseline lipophilicity relationships

Igor Shamovsky1, Stephen Connolly, Laurent David

  • 1Department of Medicinal Chemistry, AstraZeneca R&D Lund, S-22187 Lund, Sweden. igor.shamovsky@astrazeneca.com

Journal of Medicinal Chemistry
|February 9, 2008
PubMed

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