The transformative impact of stem cell core facilities in biomedical research

Area of Science:

• Biomedical Research
• Stem Cell Technology
• Regenerative Medicine

Background:

• Human pluripotent stem cell (hPSC) technologies, including induced pluripotent stem cells, gene editing, and 2D/3D models, have advanced significantly over the past three decades.
• These technological advancements have profoundly impacted various fields within biomedical research.
• The development of stem cell core facilities has been a direct consequence of these advancements.

Purpose of the Study:

• To highlight the transformative role of hPSC technologies in biomedical research.
• To emphasize the critical function of stem cell core facilities in supporting research endeavors.
• To discuss the current challenges and future prospects for the global stem cell community.

Main Methods:

• Review of advancements in human pluripotent stem cell (hPSC) technologies.
• Analysis of the impact of these technologies on disease modeling, drug discovery, and ATMPs.
• Examination of the role and function of stem cell core facilities.

Main Results:

• hPSC technologies have revolutionized disease modeling, drug discovery, and the development of advanced therapy medicinal products (ATMPs).
• Stem cell core facilities provide essential expertise, standardized workflows, and access to advanced technologies.
• These facilities are instrumental in supporting fundamental and translational research, promoting rigor and reproducibility, and fostering collaboration.

Conclusions:

• Stem cell core facilities serve as vital hubs of excellence in the scientific community.
• Addressing current challenges and capitalizing on future opportunities is essential for the global stem cell field.
• Continued innovation in hPSC technologies and core facility support will drive future biomedical breakthroughs.