Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Non-specific immunity after local immunization.

Developments in Biological Standardization

|January 1, 1976

Summary

This summary is machine-generated.

Local immunization with inactivated bacteria provides broad protection against various infections. This non-specific immunity enhances the immune response, offering protection against both bacterial and viral challenges.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

The current difficulties in fighting typhoid fever.

Das Deutsche Gesundheitswesen·2010

Same author

A year of epidemics.

Das Deutsche Gesundheitswesen·2010

Same author

[Status of typhoid prophylaxis].

Deutsche medizinische Wochenschrift (1946)·1983

Same author

[Open problems in the immunoprophylaxis against abdominal typhoid: 3rd generation vaccines].

Fortschritte der Medizin·1983

Same author

The effect of various interventions during a typhoid epidemic. Results of a simulation study.

Infection·1983

Same author

[Para-immunity after oral antigen administration].

Fortschritte der Medizin·1982

Same journal

International challenges and public policy issues.

Developments in biological standardization·2000

Same journal

Regulation of biologicals in China.

Developments in biological standardization·2000

Same journal

ICH activities on biotech topics.

Developments in biological standardization·2000

Same journal

Regulation of biologicals in the European Union.

Developments in biological standardization·2000

Same journal

Standardisation and licensing of combination vaccines based on DTP.

Developments in biological standardization·2000

Same journal

Control of foot-and-mouth disease by vaccination.

Developments in biological standardization·2000

See all related articles

Area of Science:

Immunology
Microbiology
Infectious Diseases

Background:

Local immunization strategies are explored for their potential to induce protective immune responses.
The concept of non-specific immunity, or heterologous protection, suggests a broader protective effect beyond the targeted pathogen.

Purpose of the Study:

To investigate the non-specific protective effects of local immunization using inactivated enterobacteria.
To evaluate the efficacy of oral immunization with inactivated Salmonella typhimurium against heterologous infections.

Main Methods:

Active protection tests were conducted in mice using virulent Salmonella typhimurium for oral infection.
Mice were orally immunized with heterologous inactivated enterobacteria.
Phagocytosis assays were performed to assess macrophage activity against streptococci post-immunization.

Related Experiment Videos

Main Results:

Oral immunization with inactivated Salmonella typhimurium conferred immunity against oral Salmonella typhimurium infection.
Non-specific protection was observed in a viral model; mice were protected against parapoliomyelitis virus infection after S. typhimurium immunization.
Phagocytosis rates of macrophages against streptococci significantly increased following oral or inhaled administration of heat-killed S. typhimurium.

Conclusions:

Local immunization with inactivated enterobacteria demonstrates a significant non-specific protective effect.
This approach enhances innate immune responses, providing cross-protection against unrelated bacterial and viral pathogens.
Oral and inhaled immunization routes are effective in inducing these beneficial non-specific immune effects.