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Updated: Jul 7, 2026

Coronary Artery Ligation and Intramyocardial Injection in a Murine Model of Infarction
Published on: June 7, 2011
[Transmyocardial laser revascularization]
Muzaffer Bahçivan1, Hasan Tahsin Keçeligil, Ferşat Kolbakir
1Ondokuz Mayis Universitesi, Tip Fakültesi, Kalp ve Damar Cerrahisi Anabilim Dali, Samsun, Türkiye. mbahcivan@omu.edu.tr
Insights
Transmyocardial laser revascularization (TMR) improves angina and quality of life for patients unsuitable for conventional treatments. However, TMR does not impact survival or cardiac events, with further research pending.
Area of Science:
- Cardiology
- Minimally Invasive Surgery
Context:
- Conventional revascularization methods are unsuitable for a growing number of patients with refractory angina pectoris.
- Transmyocardial laser revascularization (TMR) offers an alternative when bypass surgery or angioplasty is not indicated.
Purpose:
- To evaluate the effectiveness of Transmyocardial laser revascularization (TMR) in patients with refractory angina pectoris.
- To assess the impact of TMR on angina symptoms, quality of life, and clinical outcomes.
Summary:
- Transmyocardial laser revascularization (TMR) significantly alleviates angina symptoms and enhances the quality of life for eligible patients.
- The procedure also leads to reduced hospital readmissions and potential improvements in exercise tolerance.
- Importantly, TMR has not demonstrated an effect on survival rates, ejection fraction, cardiac events, or myocardial perfusion.
Impact:
- TMR provides a viable treatment option for select patients with refractory angina, improving symptomatic relief and daily living.
- While not affecting long-term survival or major cardiac events, TMR offers significant palliative benefits.
- Ongoing clinical trials are expected to provide further insights into the long-term efficacy and role of TMR in cardiovascular care.
Abstract:
An increasing number of patients are found to be unsuitable for revascularization by conventional approaches to the epicardial vessels. Transmyocardial laser revascularization (TMR) is a treatment choice for patients who have refractory angina pectoris when bypass surgery or percutaneous transluminal angioplasty is not indicated. Transmyocardial laser revascularization leads to significant improvements in angina. It also improves quality of life, reduces hospital readmission rates and may improve exercise tolerance. However, the technique does not effect survival, ejection fraction, cardiac events and myocardial perfusion with nuclear studies. Further results from ongoing trials are awaited with interest.
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