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Related Experiment Video

Updated: Jul 7, 2026

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

Published on: January 16, 2019

Record linkage software in the public domain: a comparison of Link Plus, The Link King, and a 'basic' deterministic

Kevin M Campbell¹, Dennis Deck, Antoinette Krupski

¹Washington State Division of Alcohol and Substance Abuse, PO Box 45330, Olympia, Washington 98504-5330, USA. campbkm@dshs.wa.gov

Health Informatics Journal

|February 9, 2008

Summary

This study compared record linkage software for unduplicating a large administrative database. The Link King and Link Plus achieved optimal accuracy, outperforming a basic deterministic algorithm for data management.

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Determining the Likelihood of Variant Pathogenicity Using Amino Acid-level Signal-to-Noise Analysis of Genetic Variation

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Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae

Detection of Homologous Recombination Intermediates via Proximity Ligation and Quantitative PCR in Saccharomyces cerevisiae

Published on: September 11, 2022

Area of Science:

Health Informatics
Data Management
Biostatistics

Background:

Accurate record linkage is crucial for unduplicating large administrative databases.
Evaluating the performance of different record linkage algorithms is essential for data quality.

Purpose of the Study:

To compare the accuracy of a deterministic record linkage algorithm with two public domain software applications: The Link King and Link Plus.
To assess the sensitivity and positive predictive values (PPVs) of these algorithms in unduplicating a large client database.

Main Methods:

A deterministic algorithm, The Link King, and Link Plus were applied to an administrative database of over 500,000 clients.
A random sample of linked records underwent blinded clerical review by four research staff.
Sensitivity and PPVs were calculated using reviewer decisions as the gold standard.

Main Results:

The Link King and Link Plus achieved optimal sensitivity and PPVs in the mid-90s.
The basic deterministic algorithm yielded a sensitivity of 79% and PPVs of 98%.

Conclusions:

The Link King is a suitable option for SAS users due to its comprehensive features.
Link Plus is a viable alternative for non-SAS users, provided programming resources are available.