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Surfactant Depletion Combined with Injurious Ventilation Results in a Reproducible Model of the Acute Respiratory Distress Syndrome (ARDS)
Published on: April 7, 2021
[Drug-induced pulmonary damage due to inhalation of a waterproof spray]
Hidetoshi Hayashi1, Tomoya Ishii, Tadashi Ishida
1Department of Respiratory Medicine, Kurashiki Central Hospital.
Abstract:
A 24-year-old woman smoked after using a waterproof spray in a poorly ventilated room. Two days later, she experienced a dry cough and dyspnea and was admitted to our hospital. A chest radiograph and CT showed ground-glass opacity. Bronchoalveolar lavage fluid yielded no specific findings but a transbronchial lung biopsy specimen revealed eosinophilic alveolitis characterized by edema in the alveolar septa. The patient recovered without any treatment subsequent to hospitalization and she remained symptom-free after discharge. It was believed that she had suffered direct pulmonary damage from inhaling waterproof spray. Among the spray components, fluorocarbon resin was the most likely causative agent.
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