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Updated: Jul 7, 2026

An Orthotopic Bladder Cancer Model for Gene Delivery Studies
Published on: December 1, 2013
[Molecular targeting therapy for bladder cancer]
Haruhito Azuma1, Yoji Katsuoka
1Department of Urology, Osaka Medical College.
Abstract:
Molecular-targeted drugs are agents that act on molecules which are specifically expressed in cancer, or on molecules whose expression is increased in cancer compared to normal tissue, and suppress the growth, infiltration and metastasis of cancer while affecting normal tissue as little as possible by selectively impairing function in cancer tissue. The major molecular targets in cancer therapy include oncogene products, growth factors and their receptors, signal-transducing molecules, hormone receptors, cell cycle-related proteins, telomerase-related molecules, apoptosis-related molecules, angiogenesis-related molecules, anticancer drug resistance/sensitivity factors, transcription factors, and molecules related to infiltration and metastasis. This paper reports on the molecular-targeted drugs currently considered for bladder cancer.
Insights
Molecular-targeted drugs selectively impair cancer cells, minimizing harm to normal tissues. This review focuses on molecular-targeted therapies currently being explored for bladder cancer treatment.
Area of Science:
- Oncology
- Pharmacology
- Molecular Biology
Background:
- Molecular-targeted drugs offer a precise approach to cancer therapy by targeting specific molecules involved in cancer development.
- These agents aim to inhibit cancer growth, invasion, and metastasis while minimizing damage to healthy tissues.
- Key molecular targets include oncogene products, growth factors, signaling molecules, and factors influencing drug resistance, apoptosis, and angiogenesis.
Purpose of the Study:
- To review the current landscape of molecular-targeted drugs under consideration for bladder cancer.
- To highlight the specific molecular targets relevant to bladder cancer therapy.
Main Methods:
- Literature review of molecular-targeted drugs and their application in bladder cancer.
- Analysis of molecular targets implicated in bladder cancer progression and treatment.
Main Results:
- Identification of various molecular targets crucial for bladder cancer, such as growth factor receptors and cell cycle regulators.
- Overview of emerging molecular-targeted drugs showing potential in preclinical and clinical studies for bladder cancer.
Conclusions:
- Molecular-targeted therapy represents a promising strategy for advancing bladder cancer treatment.
- Further research and clinical trials are essential to fully realize the potential of these targeted agents in improving patient outcomes.
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