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Updated: Jul 7, 2026

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications
08:08

Antimicrobial Characterization of Advanced Materials for Bioengineering Applications

Published on: August 4, 2018

New antimicrobial agents for the treatment of Gram-positive bacterial infections

D Y Aksoy1, S Unal

  • 1Department of Internal Medicine, Medical Faculty, Hacettepe Univrsity, Ankara, Turkey. duyguyaks@yahoo.com

Clinical Microbiology and Infection : the Official Publication of the European Society of Clinical Microbiology and Infectious Diseases
|February 12, 2008
PubMed

Insights

Antimicrobial resistance is a growing global health threat, especially for Gram-positive bacterial infections. New drugs like linezolid and daptomycin offer hope for treating resistant infections.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pharmacology

Background:

  • Antimicrobial resistance has escalated since the 1970s, complicating treatment of Gram-positive bacterial infections.
  • Multidrug-resistant organisms such as MRSA, resistant pneumococci, and VRE pose significant clinical challenges.
  • The pharmaceutical industry is actively developing novel antimicrobial agents to combat these resistant infections.

Purpose of the Study:

  • To review recently introduced and clinically developing antimicrobial agents.
  • To summarize the properties and recent study results of these new agents.
  • To discuss future treatment possibilities for resistant infections.

Main Methods:

  • Literature review of recent studies on new antimicrobial agents.
  • Analysis of properties and clinical data for agents like linezolid, quinupristin-dalfopristin, daptomycin, tigecycline, new glycopeptides, and ceftobiprole.

Main Results:

  • Several new agents including linezolid, quinupristin-dalfopristin, daptomycin, tigecycline, new glycopeptides, and ceftobiprole are available or in development.
  • These agents exhibit diverse mechanisms of action and spectrums of activity against resistant Gram-positive pathogens.
  • Recent studies demonstrate varying efficacy and safety profiles for these novel therapeutics.

Conclusions:

  • New antimicrobial agents are crucial for managing infections caused by multidrug-resistant Gram-positive bacteria.
  • Continued research and development are essential to address the evolving challenge of antimicrobial resistance.
  • These emerging therapies hold promise for improving treatment outcomes in the future.

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